In the Alternative / Unlimited Universes, You have cyborgs. Their possibly called Cybreed.
Silvio Orlandi turned into a cyborg after being munched on by BETA.
Renzo had extensive cybernetics that allowed fast healing and the abilty to somehow increase the output and control of a Feedback Protector beyond normal levels.
The 00 Unit is likely made with this technology.
- The Idea of Cybernetics increasing a Mecha's performance is also seen in Armored Core, with Human PLUS.